Table 4
|
Association studies of common DNA variants of the NRIP1 gene in relation to human endometriosis.
|
NRIP1 polymorphism (change in codon)
|
Genotypes
|
Patients (n = 59)
|
Unselected Controls (n = 94)
|
Super Controls (n = 47)
|
All Controls (n = 141)
|
Statistical Analysis*
|
|
Gly75Gly (ggg to gga)
|
aa
|
15
|
19
|
9
|
28
|
P = 0.34 (Heterozygous test)
|
|
ag
|
27
|
46
|
27
|
73
|
|
|
gg
|
17
|
28
|
11
|
39
|
|
Arg448Gly (cga to gga)
|
cc
|
44
|
83
|
40
|
123
|
P = 0.027 (Allele positivity test)
|
|
cg
|
14
|
10
|
7
|
17
|
|
|
gg
|
1
|
1
|
0
|
1
|
|
Ser803Leu (tcg to ttg)
|
cc
|
56
|
85
|
46
|
130
|
P = 0.59 (Armitage's trend test)
|
|
ct
|
3
|
9
|
1
|
10
|
|
|
tt
|
0
|
0
|
0
|
0
|
|
|
*Compares patients versus merged controls. Best p value employing tests for genetic association according to Sasieni (1997). Ile441Val and His221Arg are not analyzed due to small or null sample size in endometriosis samples. |